Systems Biology for Traditional Chinese Medicine
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The application of systems biology methods to Traditional Chinese Medicine
Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature.
Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development.
Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also:
- Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics
- Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies
- Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities
- Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines
This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.
TCM Research / 211 8.3 Introduction of Bioinformatics / 216 8.4 Bioinformatics Techniques and Their Applications in the Research of TCM / 219 8.5 Conclusions / 222 References / 224 9 STUDY OF INTEGRATED BIOMARKER SYSTEM OF DIABETIC NEPHROPATHY 228 9.1 Introduction of Diabetic Nephropathy / 228 9.2 Mogensen Staging and TCM Typing of DN / 234 9.3 The Metabonomics Study of DN / 244 9.4 Condition of Metabolism after Treatment with TangShen Formula (TSF) / 278 9.5 Genomics Study of Diabetic
individual catechins from tea polyhpenol mixture by CCC. Journal of Liquid Chromatography and Related Technologies, 24(11–12), 1723–1732. c03.indd 129 5/2/2012 9:22:47 AM 130 TECHNOLOGICAL PLATFORM OF TCM CHEMOMICS  Shibusawa, Y., Yanagida, A., Ito, A., Ichihashi, K., Shindo, H., Ito, Y. (2000). Highspeed counter-current chromatography of apple procyanidins. Journal of Chromatography A, 886(1–2), 65–73.  Tong, X.J., Fang, W.S., Zhou, J.Y., He, C.H., Chen, W.M., Fang, Q.C. (1994).
reactions and side effects as well as discovering precise applications of a drug according to genotypes of drug-related proteins; and in epigenetic mechanism and function research, explaining the molecular mechanisms of the signal, the epigenetic regulation, and the development and adaptation of an individual. 5.1.2 Methodology and Technology Platform of Genomics for TCM Because of the complexity of the components and functions of TCM, the methodology and techniques to research the
extracellular matrix (ECM) is very important for cells’ integrity, because it forms a stress-tolerating network through the linkage of myocardial cells and the capillaries of the ventricular wall. Abnormality in the constriction and relaxation function of the heart would be induced by the destruction of ECM structure. The collagenous ECM is a structure that supports the heart in its normal form. The constriction and relaxation functions of the heart would be affected by the structure of the
with white and thin fur, and smooth or deep pulse. “Prescriptions corresponding to the syndromes” not only refers to the interaction between one prescription and one syndrome, but also uses one prescription for many other syndromes and many prescriptions for one individual syndrome. This correspondence may change with time. For instance, when the syndrome changes after the prescription is taken for some time, there would be a gap period between this prescription and the syndrome. At this time,