Psychiatry as a Neuroscience

Psychiatry as a Neuroscience

Language: English

Pages: 346

ISBN: 0471496561

Format: PDF / Kindle (mobi) / ePub


Psychiatry as a Neuroscience provides an overview of recent solid advances in biological psychiatry which are of clinical relevance.

These include

* psychoneuroendocrinological and psychoimmunological findings in major depression
* genetic and neuroimaging data in schizophrenia
* molecular genetic findings in Alzheimer's disease
* neuroimaging data in obsessive-compulsive disorder.
This book will be of interest to psychiatrists and psychologists, neuroscientists, managers and policy makers.

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Health, on the behavioural, neuroendocrine and autonomic components of the stress response in adult male rhesus macaques [69]. The MOLECULAR AND CELLULAR BIOLOGY RESEARCH 47 study was carried in a double-blind, placebo-controlled fashion in monkeys exposed to an intense social stressor: namely, placement of two unfamiliar males in adjacent cages separated only by a transparent Plexiglas screen. Antalarmin significantly inhibited a repertoire of behaviours associated with anxiety and fear such

fate of the compound may be used as an index of such functions in brain regions. Gamma radiation easily penetrates the skull and brain tissue. When gamma-ray-emitting isotopes are used to label compounds that interact with brain metabolism or constituents thereof, their location in brain tissue can be externally determined by crystal detectors that emit photons, or light, when hit by gamma rays. Using systems of such scintillation detectors positioned around the head, it is possible to follow

Regardless of the aetiology, hypothyroidism leads to a number of clinical manifestations, including slowed mentation, forgetfulness, decreased hearing, cold intolerance and ataxia. Decreased energy, weight gain, depression, cognitive impairment or overt psychosis (``myxoedema madness'') may also result. Due to the overlap of symptoms with clinical depression, thyroid hormone deficiency must be ruled out in the evaluation of patients with depression. Hypothyroidism is frequently subclassified into

target endocrine gland; instead, GH acts directly on targets including bone, muscle and liver. GH also stimulates the release of somatomedin from the liver and insulin-like growth factors. GH shows pulsatile release, with highest release occurring around the time of sleep onset and extending into the first non-REM period of sleep [117]. GH release response to a variety of stimuli, including l-DOPA, a dopamine precursor [118], apomorphine, a centrally active dopamine agonist [110], and the

the response to afferent innervation, engendering functional connection between thalamic and basal forebrain cholinergic afferents. While widely distributed in the brain, it is found in the CA3 region of the hippocampus and in the reticular nucleus of the thalamus. In this regard, Clementz et al. [128] have shown that the P50 may be a subcomponent of the fast transient gamma band response emanating from thalamic mechanisms, while Erwin et al. [175] found it mirrored in the P100 recovery cycle of

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