Principles of Neural Science, Fifth Edition (Principles of Neural Science (Kandel))

Principles of Neural Science, Fifth Edition (Principles of Neural Science (Kandel))

Language: English

Pages: 1760

ISBN: 0071390111

Format: PDF / Kindle (mobi) / ePub

Now updated: the definitive neuroscience resource―from Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD, PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD

A Doody's Core Title for 2015!

900 full-color illustrations

Deciphering the link between the human brain and behavior has always been one of the most intriguing―and often challenging―aspects of scientific endeavor. The sequencing of the human genome, and advances in molecular biology, have illuminated the pathogenesis of many neurological diseases and have propelled our knowledge of how the brain controls behavior.

To grasp the wider implications of these developments and gain a fundamental understanding of this dynamic, fast-moving field, Principles of Neuroscience stands alone as the most authoritative and indispensible resource of its kind.

In this classic text, prominent researchers in the field expertly survey the entire spectrum of neural science, giving an up-to-date, unparalleled view of the discipline for anyone who studies brain and mind. Here, in one remarkable volume, is the current state of neural science knowledge―ranging from molecules and cells, to anatomic structures and systems, to the senses and cognitive functions―all supported by more than 900 precise, full-color illustrations. In addition to clarifying complex topics, the book also benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. Principles of Neural Science then proceeds with an in-depth examination of the molecular and cellular biology of nerve cells, synaptic transmission, and the neural basis of cognition. The remaining sections illuminate how cells, molecules, and systems give us sight, hearing, touch, movement, thought, learning, memories, and emotions.

The new fifth edition of Principles of Neural Science is thoroughly updated to reflect the tremendous amount of research, and the very latest clinical perspectives, that have significantly transformed the field within the last decade.

Ultimately, Principles of Neural Science affirms that all behavior is an expression of neural activity, and that the future of clinical neurology and psychiatry hinges on the progress of neural science. Far exceeding the scope and scholarship of similar texts, this unmatched guide offers a commanding, scientifically rigorous perspective on the molecular mechanisms of neural function and disease―one that you’ll continually rely on to advance your comprehension of brain, mind, and behavior.


  • The cornerstone reference in the field of neuroscience that explains how the nerves, brain, and mind function
  • Clear emphasis on how behavior can be examined through the electrical activity of both individual neurons and systems of nerve cells
  • Current focus on molecular biology as a tool for probing the pathogenesis of many neurological diseases, including muscular dystrophy, Huntington disease, and certain forms of Alzheimer’s disease
  • More than 900 engaging full-color illustrations―including line drawings, radiographs, micrographs, and medical photographs clarify often-complex neuroscience concepts
  • Outstanding section on the development and emergence of behavior, including important coverage of brain damage repair, the sexual differentiation of the nervous system, and the aging brain
  • NEW! More detailed discussions of cognitive and behavioral functions, and an expanded review of cognitive processes
  • NEW! A focus on the increasing importance of computational neural science, which enhances our ability to record the brain’s electrical activity and study cognitive processes more directly
  • NEW! Chapter-opening Key Concepts provide a convenient, study-enhancing introduction to the material covered in each chapter
  • Selected Readings and full reference citations at the close of each chapter facilitate further study and research
  • Helpful appendices highlight basic circuit theory; the neurological examination of the patient; circulation of the brain; the blood-brain barrier, choroid plexus, and cerebrospinal fluid; neural networks; and theoretical approaches to neuroscience/ul>

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find patterns common to stimuli of a particular class. Experiments using alert animals have revealed a variety of feature-detection neurons in the cortex. Some cortical neurons in area 2 respond preferentially to specific combinations of simultaneously stimulated receptors. Such orientation-sensitive neurons sense the angle of edges contacted by the skin (Figure 23-13A). This information is extremely important in reconstructing the shapes of objects. Other cells are direction sensitive. They

represent inputs from off- center lateral geniculate cells. Figure 27-12 The receptive fields of simple cells in the primary visual cortex are different and more varied than those of the neurons in the retina and lateral geniculate nucleus. A. Cells of the retina and lateral geniculate nucleus fall into two classes: on-center and off-center. The receptive fields of these neurons have a center-surround organization due to antagonistic excitatory (+) and inhibitory (-) regions. B. The

olivocerebellar lesions impair adaptation. Brain 119:1183–1198. P.852 Martin TA, Keating JG, Goodkin HP, Bastian AJ, Thach WT. 1996b. Throwing while looking through prisms. II. Specificity and storage of multiple gaze-throw calibrations. Brain 119:1199–1211. Martinez FE, Crill WE, Kennedy TT. 1971. Electrogenesis of the cerebellar Purkinje cell response in cats. J Neurophysiol. 34:348–356. McCormick DA, Thompson RF. 1984. Cerebellum: essential involvement in the classically conditioned eyelid

sensation to the anterior two-thirds of the tongue. The autonomic component of the facial nerve includes parasympathetic fibers that innervate lacrimal and salivary glands (except the parotid gland) and the cerebral vasculature. The facial nerve may suffer isolated injury in Bell's palsy, a common complication of certain viral infections. If there is a herpes zoster infection of the geniculate ganglion, small blisters may form in the outer ear canal, the ganglion's cutaneous sensory field;

axoplasm. Studies with isolated axonal components (in vitro motility assays) have clarified how membranes and other cellular constituents move along nerve processes. Anterograde transport in the axon depends on microtubules that provide an essentially stationary track on which specific organelles move by means of molecular motors. The saltatory nature of the movement is due to periodic dissociation of the organelle from the track or to collision with other structures. The idea that microtubules

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