Craniofacial Embryogenetics and Development (2nd Edition)
Geoffrey H. Sperber, Steven M. Sperber, Geoffrey D. Guttmann, Phillip V. Tobias
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Recent advances in genetics, molecular biology, diagnostic imaging and surgical techniques require a substantial understanding of prenatal development morphogenesis. The clinical significance of the normal mechanisms of embryogenesis, developmental failures and consequent craniofacial anomalies is of increasing concern to plastic and orofacial surgeons, otolaryngologists, orthodontists, neonatologists, and speech pathologists. This second edition will …….
Clinicians dealing with malformations needing comprehension of the exponential expansion of information on molecular genomics, dysgenesis, teratology and the etiology of syndromes and anomalies are served by this book’s succinct contents. While providing clinicians with a basic background for treating craniofacial anomalies, this text will also appeal to teratologists, embryologists, and anatomists.
from a single-cell to a 16-cell cluster, the morula, no larger than the original ovum (Fig. 2–4). The first 2 days of human embryo formation are controlled Figure 2–4 Initial stages of embryogenesis, depicting cell division. Note that the morula, containing up to 16 cells, is no larger than the fertilized ovum. *This duration of gestation is based upon the menstrual cycle of 28 days. Calculation from the last occurring menstruation is known as the “menstrual age” of the embryo. This menstrual
cannot rule out epigenetic influences affecting, say, the enamel organs during ontogeny. To these variegated musings the new book by the duo of Geoffrey and Steven Sperber now joined by Geoffrey Guttmann has given rise. I am confident that it will prove as great and sustainable a success as those books that have gone before under the authorship of Emeritus Professor Geoffrey Hilliard Sperber, anatomist, embryologist, anthropologist, and odontologist extraordinaire. Phillip V. Tobias FRS, FRCP,
of nucleotides that specify the sequence of amino acids that make up the primary structure of a polypeptide chain. These polypeptide chains constitute the proteins that provide the cells that form the tissues that create the organs of a developing embryo. Functionally, genes are conceived as structural, operator or regulatory genes. Analysis of an indivdual’s genetic endowment is obtained by a metaphase spread of the chromosomes (Fig. 1–1) that is organized into a karyotype for analysis (Fig.
of transverse palatal rugae develop in the mucosa covering the hard palate. They appear even before palatal fusion, which occurs at 56 days pc. The rugae, which are most prominent in the infant, hold the nipple while it is being milked by the tongue. The anterior palatal furrow is well marked during the first year of life (i.e., the active suckling period), and normally flattens out into the palatal arch after 3 or 4 years of age when suckling has been discontinued. Persistence of thumb-sucking
in ankylosis that may be unilateral or bilateral. The functionless joint results in mandibular maldevelopment together with masticatory distress of varying severity. Whereas absence of the articular disk is exceedingly rare, its perforation, resulting in intercompartmental communication, is fairly common, and not necessarily debilitating. SELECTED BIBLIOGRAPHY Ashworth GJ. The attachments of the temporomandibular joint meniscus in the human fetus. Br J Oral Maxillofac Surg 1990; 28:246–250.