Color Atlas of Dermatopathology (Dermatology: Clinical & Basic Science)
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This outstanding dermatopathology atlas emphasizes the correlation of pathological findings with clinical presentations and presents a reader-friendly approach to the diagnosis and interpretation of skin biopsy results. With an abundance of color clinical and histologic photographs, and descriptions of numerous dermatological diseases and conditions, this source is a must-have for anyone preparing for dermatology or pathology board exams, or for those desiring a strong understanding of the clinical or pathological presentations of disease.
pathologic correlation is essential as several disease entities may appear indistinguishable histologically and yet be clinically distinct. Many of these disorders present with vesicles or bullae in their early or acute forms. Epidermal spongiosis is one mechanism by which intraepidermal vesicles are formed. In general, the spongiotic dermatoses can be divided histologically into a spectrum of acute, subacute, and chronic forms (Table 3). Clinicopathologic Correlation: Clinical Feature
(onion-skinning) of vessel wall constituentsb (concentric proliferation of pericytes and smooth muscle cells) Lumenal obliteration (endarteritis obliterans)b Intimal or medial proliferation of cellular elements leading to lumenal occlusion with preservation of the internal elastic lamina Segmental or complete loss of elastic lamina in medium and large vessels associated with acellular scar tissuea Reactive angioendotheliomatosis Neo-vascularization of vessel adventitia a Required for diagnosis
histiocytes generally in the upper half of the dermis surrounded by a mantle of lymphocytes (Figs. 3B and D) and associated with overlying epidermal thinning (rather than hyperplasia as seen in primary tuberculosis inoculation). 108 B Grant-Kels Usually none or minimal caseation necrosis (Figs. 2D and 3D) (as seen more commonly in primary tuberculosis inoculation, scrofuloderma, and miliary tuberculosis) and no identifiable acid-fast bacilli (as can be seen in early primary tuberculosis
P, Ziegler G, Ortonne JP. Multicentric reticulohistiocytosis. Immunohistological and ultrastructural study: A pathology of dendritic cell lineage. Am J Dermatopathol 1992; 14:418–425. 2. Rapini RP. Multicentric reticulohistiocytosis. Clinics in Dermatology 1993; 11:107–111. 3. Zelger B, Cerio R, Soyer HP, Misch K, Orchard G, Wilson-Jones E. Reticulohistiocytoma and multicentric reticulohistiocytosis. Histopathologic and immunophenotypic distinct entities. Am J Dermatopathol 1994; 16:577– 584.
cells” lined by basophilic granular calcium deposition (H & E stain, original magnification 100x). 162 Robinson-Bostom Figure 7 (A) Erythematous nodules on medial lower leg. (B) Septal neutrophilic inflammation with liquefactive necrosis and collagenolysis [hematoxylin and eosin (H & E) stain, original magnification 40x]. (C) “Splaying of neutrophils” between collagen bundles in the reticular dermis (H & E stain, original magnification 200x). (D) Dermal collagenolysis (H & E stain, original