Clinical Functional MRI: Presurgical Functional Neuroimaging (Medical Radiology)

Clinical Functional MRI: Presurgical Functional Neuroimaging (Medical Radiology)

Language: English

Pages: 271

ISBN: 364214005X

Format: PDF / Kindle (mobi) / ePub


This is the first textbook on clinical fMRI. It is devoted to preoperative fMRI in patients with brain tumors and epilepsies, which are the most well-established clinical applications. State-of-the-art fMRI procedures are presented, with detailed consideration of the physiological and methodological background, imaging and data processing, normal and pathological findings, diagnostic possibilities and limitations, and other related techniques.

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designs, especially for cognitive tasks. An important advantage of eventrelated designs is the possibility to present stimuli in a randomized order (Fig. 2.10), which avoids cognitive adaptation strategies of the subjects. Such cognitive adaptations are likely to occur in block designs since a subject knows what type of stimuli to expect within a block after having experienced the first few trials. Another important advantage of event-related designs is that the response profi le for different

allows integrating correction for multiple comparisons resulting in thresholding values similar to the ones obtained with the false discovery rate approach. 2.4.2.4 Data-Driven Analysis Methods 2.4.2.3 Brain Normalization As described earlier, brain normalization methods have an important influence on the quality of group analyses, since optimization of the standard analysis does not lead to substantial improvements if voxel time courses are concatenated from nonmatching brain regions. The

the reasons for the occasional discrepancies been investigated. For example, Hammeke and colleagues reported a significant discrepancy between fMRI and Wada lateralization indices in approximately one in ten patients (Hammeke, Bellgowan et al. 2000). In particular temporal tumors of the dominant hemisphere have been reported to lead to falsenegative activation of the dominant hemisphere (Westerveld, Stoddard and McCarthy 1999; Gaillard, Bookheimer and Cohen 2000). Finally, it has to be emphasized

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